Over the years, the recurring themes in Clark's work are gender and ethnicity, the nexus of employment and unemployment, and the persistence of material culture into the electronic era. Clark also collaborates with Michael Peterson under the group name Spatula and Barcode on creative projects that explore hospitality and discourse.
Parallel with her creative practice, Clark has published critical and scholarly essays in print journals including Theatre Topics (2003), TDR (2011), Performance Research (2008, 2011), electronic journals including Flow TV (2009) and Performance Paradigm (2009), and anthologies including Performance and Place (Palgrave 2006), Blaze (Cambridge 2007), The Object Reader (Routledge, 2008), The Art of Truth Telling After Authoritarian Rule (Wisconsin 2005) The Memory Market in Latin America (Duke, 2011). She has lectured all over the United States and in Argentina, Brasil, Croatia, Germany, Ghana, England, Indonesia, Korea, the Netherlands, Portugal, Singapore, and Wales.
Since 2001, Clark has been working on a global comparative study of trauma memorials. The monograph in progress Always Already Again: Trauma Tourism and the Politics of Memory Culture includes research on apartheid memorials in South African, atomic bomb sites in Japan, clandestine torture centers in Argentina and Chile, commemoration of the American War in Vietnam, concentration camps in Germany and Poland, genocide memorials in Rwanda and Cambodia, and slave forts in Ghana.